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2-Bromopyrimidine GMP Manufacturer Global Trade 4595-60-2 with Fast Delivery
- Molecular Formula:C4H3BrN2
- Molecular Weight:158.985
- Appearance/Colour:off-white crystalline powder
- Vapor Pressure:0.0353mmHg at 25°C
- Melting Point:55-57 °C(lit.)
- Refractive Index:1.568
- Boiling Point:249.9 °C at 760 mmHg
- PKA:-1.59±0.13(Predicted)
- Flash Point:105 °C
- Density:1.726 g/cm3
2-Bromopyrimidine(Cas 4595-60-2) Usage
|
Preparation |
The recent synthesis of 2-bromopyrimidine by diazotization of 2-aminopyrimidine in hydrobromic acid has furnished a convenient starting material for other 2-substituted pyrimidines. |
|
General Description |
2-Bromopyrimidine undergoes microwave-assisited aminocarbonylation at C-2 with palladium and Mo(CO)6. |
InChI:InChI=1/C4H3BrN2/c5-4-6-2-1-3-7-4/h1-3H
4595-60-2 Relevant articles
Synthesis method of 2-bromopyrimidine
-
Paragraph 0011; 0035-0043, (2021/10/30)
The invention discloses a synthesis meth...
Electron-deficient heteroarenium salts: An organocatalytic tool for activation of hydrogen peroxide in oxidations
?turala, Ji?í,Bohá?ová, Soňa,Chudoba, Josef,Metelková, Radka,Cibulka, Radek
, p. 2676 - 2699 (2015/03/18)
A series of monosubstituted pyrimidinium...
Silyl-mediated halogen/halogen displacement in pyridines and other heterocycles
Schlosser, Manfred,Cottet, Fabrice
, p. 4181 - 4184 (2007/10/03)
Heating with bromotrimethylsilane conver...
The synthesis of substituted pyridylpyrimidine fungicides using palladium-catalysed cross-coupling reactions
Hargreaves, Stephanie L.,Pilkington, Brian L.,Russell, Sally E.,Worthington, Paul A.
, p. 1653 - 1656 (2007/10/03)
Various substituted phenyl, pyridyl and ...
4595-60-2 Process route
-
-
1722-12-9,1195939-87-7
2-chloropyrimidine
-
-
4595-60-2
2-bromopyrimidine
| Conditions | Yield |
|---|---|
|
With
trimethylsilyl bromide;
In
various solvent(s);
for 4h;
Heating;
|
87% |
|
With
cis-N,N'-dimethyl-1,2-diaminocyclohexane; sodium bromide; copper(I) bromide;
In
N,N-dimethyl-formamide;
at 120 ℃;
Reagent/catalyst;
Solvent;
Inert atmosphere;
Sealed tube;
|
86% |
|
With
phosphorus tribromide;
|
80% |
-
-
109-12-6
2-aminopyrimidine
-
-
4595-60-2
2-bromopyrimidine
| Conditions | Yield |
|---|---|
|
With
hydrogen bromide; sodium bromide; sodium nitrite;
In
water;
at -10 - -5 ℃;
for 3h;
|
27% |
4595-60-2 Upstream products
-
1722-12-9
2-chloropyrimidine
-
109-12-6
2-aminopyrimidine
4595-60-2 Downstream products
-
4595-66-8
4-
-3,4-dihydro-2-brom-pyrimidin -
116470-67-8
2-(trifluoromethyl)pyrimidine
-
86732-39-0
octahydro-2-benzyl-5-(2-pyrimidinyl)pyrrolo<3,4-c>pyrrole
-
77916-96-2
1-<4-(2-pyrimidinylamino)benzyl>-2,3-dioxopiperazine
