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Manufacturer supply high quality Dantrolene 7261-97-4 with GMP standards
- Molecular Formula:C14H10 N4 O5
- Molecular Weight:314.257
- Melting Point:279-280°
- Refractive Index:1.6000 (estimate)
- Boiling Point:453.94°C (rough estimate)
- PKA:7.68±0.10(Predicted)
- PSA：120.73000
- Density:1.57 g/cm3
- LogP:2.53040
Dantrolene(Cas 7261-97-4) Usage
|
Therapeutic Function |
Muscle relaxant |
|
Air & Water Reactions |
Slightly water soluble. Dantrolene may be sensitive to heat and air . |
|
Health Hazard |
SYMPTOMS: When ingested, symptoms of exposure may include drowsiness, dizziness, weakness, general malaise, fatigue, diarrhea, constipation, gastrointestinal bleeding, anorexia, abdominal cramps, hepatitis, speech disturbance, seizure, headache, light-headedness, insomnia, tachycardia, phlebitis, mental depression, mental confusion, nervousness, abdominal hair growth, rash, sweating, backache, chills and fever. |
|
Fire Hazard |
Flash point data for Dantrolene are not available. Dantrolene is probably combustible. |
|
Definition |
ChEBI: The hydrazone resulting from the formal condensation of 5-(4-nitrophenyl)furfural with 1-aminohydantoin. |
|
General Description |
Crystals (in aqueous DMF). |
InChI:InChI=1/C14H10N4O5/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22/h1-7H,8H2,(H,16,19,20)/b15-7+
7261-97-4 Relevant articles
SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF DANTROLENE AND SODIUM DANTROLENE
Oleinik, A. F.,Andreeva, N. I.,Syubaev, R. D.,Golovina, S. M.,Vozyakova, T. I.
, p. 310 - 312 (1984)
-
Mechanochemical Preparation of Protein : hydantoin Hybrids and Their Release Properties
Colacino, Evelina,Porcheddu, Andrea,Solin, Niclas,Wang, Lei,Yuan, Yusheng
, (2021/12/14)
Mechanochemistry is a versatile methodol...
Direct (Hetero)arylation of Heteroarenes Catalyzed by Unsymmetrical Pd-PEPPSI-NHC Complexes under Mild Conditions
Song, A-Xiang,Zeng, Xiao-Xiao,Ma, Bei-Bei,Xu, Chang,Liu, Feng-Shou
, p. 3524 - 3534 (2020/10/09)
With the aim of developing a facile and ...
Dantrolene prodrug and method for using same
-
Paragraph 0308-0310; 0313-0315, (2020/07/15)
The disclosure is directed to a dantrole...
Continuous Visible-Light Photoflow Approach for a Manganese-Catalyzed (Het)Arene C?H Arylation
Liang, Yu-Feng,Steinbock, Ralf,Yang, Long,Ackermann, Lutz
supporting information, p. 10625 - 10629 (2018/08/01)
Manganese photocatalysts enabled versati...
7261-97-4 Process route
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![1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt](/upload/2026/10/b608a10ae1304a8bb75fcdc945f9f390_addf65b8-2139-472b-b13f-0d00879f3cb8.png)
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14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
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-
7261-97-4
dantrolene
| Conditions | Yield |
|---|---|
|
With
acetic acid;
In
N,N-dimethyl-formamide;
at 20 ℃;
|
98% |
-
-
6301-02-6
1-aminohydantoin
-
-
7147-77-5
5-(4-nitrophenyl)-2-furaldehyde
-
-
7261-97-4
dantrolene
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
water; N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 1h;
|
96% |
|
In
water; N,N-dimethyl-formamide;
|
81% |
|
With
hydrogenchloride;
In
water; N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 1h;
|
51% |
7261-97-4 Upstream products
-
6301-02-6
1-aminohydantoin
-
7147-77-5
5-(4-nitrophenyl)-2-furaldehyde
-
2827-56-7
1-aminohydantoin hydrochloride
-
98-01-1
furfural
7261-97-4 Downstream products
-
62452-00-0
3-<3-(N-tert-butoxycarbonylamino)-1-oxopropyl-1-<<5-(4-nitrophenyl)-2-furanyl>methylene>amino>-2,4-imidazolidinedione
-
14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
