What is the Cyclopenthiazide?

Cyclopenthiazide is crystals, while it's Molecular Formula is C 13 H 18 ClN 3 O 4 S 2 . crystals Antihypertensive;Sodium Chloride Symporter Inhibitor

What is the CAS number for Cyclopenthiazide?

The CAS number of Cyclopenthiazide is 742-20-1.

What is Cyclopenthiazide (742-20-1) used for?

Cyclopenthiazide is a thiazide diuretic, a medication that promotes the excretion of water and electrolytes, particularly sodium and chloride, by inhibiting the sodium chloride symporter in the kidneys. Used in Pharmaceutical Industry: Cyclopenthiazide is used as an antihypertensive agent for the treatment of hypertension, helping to lower blood pressure and reduce the risk of cardiovascular complications. Used in Nephrology: Cyclopenthiazide is used as a diuretic for the treatment of edema caused by kidney disease, aiding in the management of fluid retention and alleviating symptoms associated with kidney dysfunction. Used in Hepatology: Cyclopenthiazide is used as a diuretic for the treatment of edema caused by liver cirrhosis, helping to reduce fluid accumulation and improve the overall condition of patients with liver-related issues. Used in Gynecology: Cyclopenthiazide is used as a diuretic for the treatment of pre-menstrual syndrome-related edema, providing relief from fluid retention and associated discomfort during the menstrual cycle.InChI:InChI=1/C13H18ClN3O4S2/c14-9-6-10-12(7-11(9)22(15,18)19)23(20,21)17-13(16-10)5-8-3-1-2-4-8/h6-8,13,16-17H,1-5H2,(H2,15,18,19)

What is the Cyclopenthiazide?

Cyclopenthiazide is crystals, while it's Molecular Formula is C 13 H 18 ClN 3 O 4 S 2 . crystals Antihypertensive;Sodium Chloride Symporter Inhibitor

What is the CAS number for Cyclopenthiazide?

The CAS number of Cyclopenthiazide is 742-20-1.

What is Cyclopenthiazide (742-20-1) used for?

Cyclopenthiazide is a thiazide diuretic, a medication that promotes the excretion of water and electrolytes, particularly sodium and chloride, by inhibiting the sodium chloride symporter in the kidneys. Used in Pharmaceutical Industry: Cyclopenthiazide is used as an antihypertensive agent for the treatment of hypertension, helping to lower blood pressure and reduce the risk of cardiovascular complications. Used in Nephrology: Cyclopenthiazide is used as a diuretic for the treatment of edema caused by kidney disease, aiding in the management of fluid retention and alleviating symptoms associated with kidney dysfunction. Used in Hepatology: Cyclopenthiazide is used as a diuretic for the treatment of edema caused by liver cirrhosis, helping to reduce fluid accumulation and improve the overall condition of patients with liver-related issues. Used in Gynecology: Cyclopenthiazide is used as a diuretic for the treatment of pre-menstrual syndrome-related edema, providing relief from fluid retention and associated discomfort during the menstrual cycle.InChI:InChI=1/C13H18ClN3O4S2/c14-9-6-10-12(7-11(9)22(15,18)19)23(20,21)17-13(16-10)5-8-3-1-2-4-8/h6-8,13,16-17H,1-5H2,(H2,15,18,19)

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Cyclopenthiazide

Chemical Name: Cyclopenthiazide
CAS: 742-20-1
Purity: 99%

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Product Detail

Factory Sells Best Quality Cyclopenthiazide 742-20-1 with steady supply

Molecular Formula: C₁₃H₁₈ClN₃O₄S₂
Molecular Weight: 379.889
Appearance/Colour: crystals
Vapor Pressure: 1.29E-14mmHg at 25°C
Melting Point: 238-242ºC
Refractive Index: 1.6
Boiling Point: 605.6 °C at 760 mmHg
PKA: 9.00±0.40(Predicted)
Flash Point: 320.1 °C
PSA： 135.12000
Density: 1.471 g/cm³
LogP: 4.92630

Cyclopenthiazide(Cas 742-20-1) Usage

World Health Organization (WHO)	Cyclopenthiazide, a thiazide diuretic, was introduced in 1968. It continues to be used mainly in combination drugs.
Drug interactions	Potentially hazardous interactions with other drugs Analgesics: increased risk of nephrotoxicity with NSAIDs; antagonism of diuretic effect. Anti-arrhythmics: hypokalaemia leads to increased cardiac toxicity; effects of lidocaine and mexiletine antagonised. Antibacterials: avoid administration with lymecycline. Antidepressants: increased risk of hypokalaemia with reboxetine; enhanced hypotensive effect with MAOIs; increased risk of postural hypotension with tricyclics. Antiepileptics: increased risk of hyponatraemia with carbamazepine. Antifungals: increased risk of hypokalaemia with amphotericin. Antihypertensives: enhanced hypotensive effect; increased risk of first dose hypotension with postsynaptic alpha-blockers like prazosin; hypokalaemia increases risk of ventricular arrhythmias with sotalol. Antipsychotics: hypokalaemia increases risk of ventricular arrhythmias with amisulpride; enhanced hypotensive effect with phenothiazines; hypokalaemia increases risk of ventricular arrhythmias with pimozide - avoid. Atomoxetine: hypokalaemia increases risk of ventricular arrhythmias. Cardiac glycosides: increased toxicity if hypokalaemia occurs. Ciclosporin: increased risk of nephrotoxicity and possibly hypomagnesaemia. Cytotoxics: increased risk of ventricular arrhythmias due to hypokalaemia with arsenic trioxide; increased risk of nephrotoxicity and ototoxicity with platinum compounds. Lithium: excretion reduced, increased toxicity
Metabolism	Cyclopenthiazide appears to be entirely excreted unchanged in the urine.

InChI:InChI=1/C13H18ClN3O4S2/c14-9-6-10-12(7-11(9)22(15,18)19)23(20,21)17-13(16-10)5-8-3-1-2-4-8/h6-8,13,16-17H,1-5H2,(H2,15,18,19)

742-20-1 Process route

: 92017-67-9
6-chloro-3-cyclopentylmethyl-1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide

: 742-20-1,96783-05-0,96783-06-1
cyclopenthiazide

Conditions

Conditions	Yield
With sodium tetrahydroborate; aluminium trichloride; In tetrahydrofuran;

: 121-30-2
chloraminophenamide

: 5623-81-4
2-cyclopentylacetaldehyde

: 742-20-1,96783-05-0,96783-06-1
cyclopenthiazide

Conditions

Conditions	Yield
With hydrogenchloride; In ethanol; for 12h; Ambient temperature;

742-20-1 Upstream products

121-30-2
chloraminophenamide
5623-81-4
2-cyclopentylacetaldehyde
92017-67-9
6-chloro-3-cyclopentylmethyl-1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide