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4,4'-pentamethylenedioxydibenzonitrile

  • Chemical Name: 4,4'-pentamethylenedioxydibenzonitrile
  • CAS: 7467-71-2
  • Purity: 99%
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Cost-effective and customizable 4,4'-pentamethylenedioxydibenzonitrile 7467-71-2 for sale

  • Molecular Formula:C19H18 N2 O2
  • Molecular Weight:306.364
  • Boiling Point:515.4°Cat760mmHg 
  • Flash Point:199.7°C 
  • Density:1.16g/cm3 

7467-71-2 Relevant articles

Small Molecule Inhibitors of Ca2+-S100B Reveal Two Protein Conformations

Cavalier, Michael C.,Ansari, Mohd. Imran,Pierce, Adam D.,Wilder, Paul T.,McKnight, Laura E.,Raman, E. Prabhu,Neau, David B.,Bezawada, Padmavani,Alasady, Milad J.,Charpentier, Thomas H.,Varney, Kristen M.,Toth, Eric A.,MacKerell, Alexander D.,Coop, Andrew,Weber, David J.

, p. 592 - 608 (2016/02/09)

The drug pentamidine inhibits calcium-de...

Biological Efficacy and Toxicity of Diamidines in Myotonic Dystrophy Type 1 Models

Siboni, Ruth B.,Bodner, Micah J.,Khalifa, Muhammad M.,Docter, Aaron G.,Choi, Jessica Y.,Nakamori, Masayuki,Haley, Michael M.,Berglund, J. Andrew

, p. 5770 - 5780 (2015/08/24)

Myotonic dystrophy type 1 (DM1) is a dis...

ARYL DIAMIDINES AND PRODRUGS THEREOF FOR TREATING MYOTONIC DYSTROPHY

-

Paragraph 0115, (2013/11/05)

Disclosed herein are compounds (for exam...

Structure-activity study of pentamidine analogues as antiprotozoal agents

Bakunova, Svetlana M.,Bakunov, Stanislav A.,Patrick, Donald A.,Kumar, E. V. K. Suresh,Ohemeng, Kwasi A.,Bridges, Arlene S.,Wenzler, Tanja,Barszcz, Todd,Jones, Susan Kilgore,Werbovetz, Karl A.,Brun, Reto,Tidwell, Richard R.

scheme or table, p. 2016 - 2035 (2009/12/31)

Diamidine 1 (pentamidine) and 65 analogu...

7467-71-2 Process route

1,5-dibromo-pentane
111-24-0

1,5-dibromo-pentane

4-cyanophenol
767-00-0

4-cyanophenol

4,4′-(pentane-1,5-diylbis(oxy))dibenzonitrile
7467-71-2

4,4′-(pentane-1,5-diylbis(oxy))dibenzonitrile

Conditions
Conditions Yield
With sodium hydride; In N,N-dimethyl-formamide; at 80 ℃; for 1h;
95.7%
With potassium carbonate; In 1,4-dioxane; for 120h; Reflux;
75%
With sodium; In ethanol;
74%
With sodium ethanolate; for 48h; Heating;
With sodium hydroxide; Yield given. Multistep reaction; 1.) C2H5OH, reflux, 1 h, 2.) C2H5OH, reflux, 3 h;
With potassium carbonate; In N,N-dimethyl-formamide; Reflux;
With potassium carbonate; In acetonitrile; Reflux;
With caesium carbonate; In acetone; for 14h; Reflux; Inert atmosphere;
4-cyanophenyl acetate
13031-41-9

4-cyanophenyl acetate

4,4′-(pentane-1,5-diylbis(oxy))dibenzonitrile
7467-71-2

4,4′-(pentane-1,5-diylbis(oxy))dibenzonitrile

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 88 percent / 4percent KOH / ethanol / 0.33 h / Heating
2: 1.) aq. NaOH / 1.) C2H5OH, reflux, 1 h, 2.) C2H5OH, reflux, 3 h
With potassium hydroxide; sodium hydroxide; In ethanol;

7467-71-2 Upstream products

  • 111-24-0
    111-24-0

    1,5-dibromo-pentane

  • 3328-57-2
    3328-57-2

    sodium 4-cyanophenolate

  • 767-00-0
    767-00-0

    4-cyanophenol

  • 13031-41-9
    13031-41-9

    4-cyanophenyl acetate

7467-71-2 Downstream products

  • 1252-44-4
    1252-44-4

    4,4'-pentanediyldioxy-bis-benzimidic acid diethyl ester

  • 224054-40-4
    224054-40-4

    4,4'-pentanediyldioxy-bis-benzylamine

  • 84223-65-4
    84223-65-4

    2,2'-di-2-imidazolin-dihydrochlorid

  • 100-33-4
    100-33-4

    pentamidine

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