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3-Picolyl chloride hydrochloride
- Chemical Name: 3-Picolyl chloride hydrochloride
- CAS: 6959-48-4
- Purity: 99%
Good factory supply good 3-Picolyl chloride hydrochloride 6959-48-4
- Molecular Formula:C6H6ClN.HCl
- Molecular Weight:164.034
- Appearance/Colour:White to pale brown solid
- Melting Point:137-143 °C
- Boiling Point:210 °C at 760 mmHg
- Flash Point:100.5 °C
- PSA：12.89000
- LogP:2.62240
3-Picolyl chloride hydrochloride(Cas 6959-48-4) Usage
|
General Description |
Yellow powder or yellow-tan solid with an irritating odor. |
|
Air & Water Reactions |
Hygroscopic. Water soluble. |
|
Reactivity Profile |
3-Picolyl chloride hydrochloride is incompatible with strong oxidizing agents and strong bases. |
|
Fire Hazard |
Flash point data for 3-Picolyl chloride hydrochloride are not available; however, 3-Picolyl chloride hydrochloride is probably combustible. |
|
Safety Profile |
Suspected carcinogen with experimental carcinogenic data. Poison by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and Cl-. |
InChI:InChI=1/C6H6ClN.ClH/c7-4-6-2-1-3-8-5-6;/h1-3,5H,4H2;1H
6959-48-4 Relevant articles
Synthesis method of 3-chloromethylpyridine hydrochloride
-
Paragraph 0020; 0024; 0025; 0029; 0030; 0034, (2020/05/05)
The invention belongs to the field of or...
PYRIMIDINE AND PYRAZINE HDAC1,2 INHIBITORS
-
Page/Page column 37, (2020/05/19)
Provided herein are compounds, pharmaceu...
A 3 - chloromethyl pyridine hydrochloride synthetic method
-
Paragraph 0024; 0025; 0029; 0034, (2019/05/28)
The invention belongs to the field of or...
Synthesis method of 3-picolyl chloride hydrochloride
-
Paragraph 0020; 0021; 0023; 0024; 0025; 0026; 0027, (2018/09/11)
The invention belongs to the field of or...
6959-48-4 Process route
-
-
100-55-0
3-hydroxymethylpyridin
-
-
6959-48-4
3-chloromethylpyridinium chloride
| Conditions | Yield |
|---|---|
|
With
thionyl chloride;
at 60 ℃;
for 16h;
|
86% |
|
With
thionyl chloride;
In
chloroform;
at 0 ℃;
Reflux;
|
63.6% |
|
With
thionyl chloride;
|
26.9 mg |
|
With
thionyl chloride;
In
methanol;
|
26.2 g |
|
With
thionyl chloride;
In
dichloromethane;
at 0 - 60 ℃;
for 1.25h;
|
-
-
108-99-6
3-Methylpyridine
-
-
6959-48-4
3-chloromethylpyridinium chloride
| Conditions | Yield |
|---|---|
|
3-Methylpyridine;
With
hydrogenchloride;
at 0 ℃;
for 9h;
under 760.051 Torr;
Large scale;
With
chlorine;
at 110 - 125 ℃;
for 8h;
Temperature;
Large scale;
|
93.26% |
|
Multi-step reaction with 4 steps
1: potassium permanganate / water / 0.5 h / 80 - 90 °C
2: sulfuric acid
3: aluminum (III) chloride; sodium tetrahydroborate / tetrahydrofuran; toluene / 0 - 5 °C
4: thionyl chloride
With
aluminum (III) chloride; sodium tetrahydroborate; potassium permanganate; thionyl chloride; sulfuric acid;
In
tetrahydrofuran; water; toluene;
|
6959-48-4 Upstream products
-
100-55-0
3-hydroxymethylpyridin
-
500-22-1
3-pyridinecarboxaldehyde
-
108-99-6
3-Methylpyridine
-
59-67-6
nicotinic acid
6959-48-4 Downstream products
-
6443-85-2
3-pyridinylacetonitrile
-
4262-04-8
2-((pyridin-3-ylmethyl)thio)pyridine
-
86669-38-7
(γ-n-butyl α-3-picolyl) methotrexate
-
79615-42-2
2-amino-4-<4-(3-pyridylmethoxy)phenyl>thiazole
